A murine model for oral infection with a primate rotavirus (simian SA11).
AUTOR(ES)
Offit, P A
RESUMO
Simian rotavirus SA11 was shown to replicate in the gastrointestinal tracts of infant mice after oral inoculation. Clinical symptoms, histopathological changes in the small intestinal mucosa, and the type-specific humoral immune response were all characteristic of rotavirus-induced gastroenteritis. The availability of this small animal model for the study of a primate rotavirus infection should expedite analysis of the immune response necessary for protection against challenge.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254422Documentos Relacionados
- Simian rotavirus SA11 strains.
- Protection of agammaglobulinemic piglets from porcine rotavirus infection by antibody against simian rotavirus SA-11.
- Simian rotavirus SA11 segment 11 contains overlapping reading frames.
- Simian rotavirus SA11 replication in cell cultures.
- Biochemical mapping of the simian rotavirus SA11 genome.
