A Mutant Transcription Factor That is Activated by 3′:5′-Cyclic Guanosine Monophosphate

AUTOR(ES)

Sanders, Richard

RESUMO

We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P- mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3′:5′-cyclic GMP in addition to their normal effector, 3′:5′-cyclic AMP.

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