A new rRNA processing mutant of Saccharomyces cerevisiae.

AUTOR(ES)

Lindahl, L

RESUMO

We have identified from a collection of temperature sensitive yeast mutants strains which fail to process rRNA normally. Characterization of one such mutant is reported here. This strain accumulates increased amounts of the 35S primary transcript, '24S' molecules extending from the transcription start site to the 5.8S region, and two classes of 5.8S rRNA with 5' extensions of 7 and 149 bases, respectively. We show that this pleiotropic change in the rRNA processing pattern is due to a single mutation. Possible models for the function of the mutated gene are discussed.

Documentos Relacionados

• The rRNA enhancer regulates rRNA transcription in Saccharomyces cerevisiae.
• A polymerase switch in the synthesis of rRNA in Saccharomyces cerevisiae.
• Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.
• Location of the 5.8S rRNA gene of Saccharomyces cerevisiae.
• Polyadenylation of rRNA in Saccharomyces cerevisiae