A New Straightforward Synthesis of 2', 3'-Didehydro-2', 3'-dideoxy-2'-(2"- (trimethylsilyl)ethylthio)thymidine, Key Intermediate for the Synthesis of 2'-Substituted Thionucleosides

AUTOR(ES)

Oliveira, Maralise P., Franco, Lucas L., Lima, Maria C. A., Simões, Cláudia M. O., Galdino, Suely L., Pitta, Ivan R., Décout, Jean-Luc, Alves, Ricardo J.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

We describe herein a straightforward and efficient preparation of 2',3'-dideoxy-2'-(2''- (trimethylsilyl)ethylthio)thymidine, which allows the preparation of diverse potentially antiviral and/or anticancer nucleosides (disulfides, thiols, sulfides, thiocyanates).

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