A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

AUTOR(ES)

Hjelmeland, L M

RESUMO

The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.

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