A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

AUTOR(ES)

Sieburth, Derek S.

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK–Ras–MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A-B mutations suppress the Multivulva phenotype of an activated ras mutation and enhance the Vulvaless phenotype of mutations in lin-45 raf, sur-8, or mpk-1. Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling.

Documentos Relacionados

• Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals
• Signaling pathways in Ras-mediated tumorigenicity and metastasis
• Caenorhabditis elegans SUR-5, a Novel but Conserved Protein, Negatively Regulates LET-60 Ras Activity during Vulval Induction
• ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis
• Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction