A Quantitative Test of the Neutral Theory Using Pooled Allozyme Data
AUTOR(ES)
Skibinski, DOF.
RESUMO
Neutral theory predicts a positive correlation between the amount of polymorphism within species and evolutionary rate. Previous tests of this prediction using both allozyme and DNA data have led to conflicting conclusions about the influence of selection and mutation drift. It is argued here that quantitative conclusions about the adequacy of neutral theory can be obtained by analyzing genetic data pooled from many sources. Using this approach, a large database containing information on allozyme variation in over 1500 species is used to examine the relationship between heterozygosity and genetic distance. The results provide support for the hypothesis that a major percentage of protein variation can be explained by variation in neutral mutation rate, and a minor percentage by strong selection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1205622Documentos Relacionados
- A Test of Neutral Molecular Evolution Based on Nucleotide Data
- A Statistical Test of a Neutral Model Using the Dynamics of Cytonuclear Disequilibria
- A simple test of expected utility theory using professional traders
- The sequential therapy regimen for Helicobacter pylori eradication: a pooled‐data analysis
- Molecular clock of viral evolution, and the neutral theory.
