A role for endogenous glucocorticoids in wound repair
AUTOR(ES)
Grose, Richard
FONTE
Oxford University Press
RESUMO
Exogenous glucocorticoids are known to inhibit wound repair, but the roles and mechanisms of action of endogenous glucocorticoids during the healing process are as yet unknown. Therefore, we wounded mice expressing a DNA-binding-defective mutant version of the glucocorticoid receptor (GRdim mice) and also analysed fibroblasts from these animals in vitro. We found a remarkably enlarged granulation tissue with a high fibroblast density in GRdim mice. This difference is likely to result from an increased migratory and proliferative capacity of GRdim fibroblasts and from elevated expression levels of soluble factors involved in granulation tissue formation in wounds of GRdim mice. In spite of the larger granulation tissue seen in early wounds, late wounds appeared normal, most likely due to an enhanced ability of GRdim fibroblasts to contract collagen. These results demonstrate an as yet unidentified role of endogenous glucocorticoids in the regulation of wound repair.
