A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory
AUTOR(ES)
Runyan, Jason D.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The prefrontal cortex is involved in the integration and interpretation of information for directing thoughts and planning action. Working memory is defined as the active maintenance of information in mind and is thought to lie at the core of many prefrontal functions. Although dopamine and other neurotransmitters have been implicated, the intracellular events activated by their receptors that influence working memory are poorly understood. We demonstrate that working memory involves transient changes in prefrontal Gq/11-signaling and in calcium-dependent intracellular protein phosphatase and kinase activity. Interestingly, inhibition of the calcium activated phosphatase calcineurin impaired, while calcium/calmodulin dependent kinase II (CaMKII) and calcium-dependent protein kinase C (PKC) enhanced, working memory. Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1074327Documentos Relacionados
- Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activities
- Calcium-sensitive and insensitive transient outward current in rabbit ventricular myocytes.
- Membrane perturbation: studies employing a calcium-sensitive dye, arsenazo III, in liposomes.
- Membrane fusion: studies with a calcium-sensitive dye, arsenazo III, in liposomes.
- Intracellular calcium measured with calcium-sensitive micro-electrodes and Arsenazo III in voltage-clamped Aplysia neurones.
