A second form of the beta subunit of signal-transducing G proteins.

AUTOR(ES)

Gao, B

RESUMO

A complementary DNA (cDNA) has been isolated that encodes a second form of the beta subunit of signal-transducing guanine nucleotide-binding regulatory proteins (G proteins). The cDNA corresponds to a 1.8-kilobase mRNA, and nucleotide sequence analysis indicates that the encoded polypeptide consists of 340-amino acid residues with a Mr of 37,335. Although the deduced polypeptide is the same size as that reported previously for the beta subunit, 10% of the amino acid residues are different. Furthermore, the 5' and 3' non-translated regions of this cDNA show no significant homology with those reported previously for cDNAs that encode the beta subunit. These data refute prior conclusions that there is only one form of the G protein beta subunit.

Documentos Relacionados

• The Vibrio cholerae acfB colonization determinant encodes an inner membrane protein that is related to a family of signal-transducing proteins.
• Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons.
• Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli.
• Site-directed mutagenesis of the phosphocarrier protein. IIIGlc, a major signal-transducing protein in Escherichia coli.
• Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.