A Single-Copy Gene Encodes Kex1, a Serine Endoprotease of Pneumocystis jiroveci

AUTOR(ES)

Kutty, Geetha

FONTE

American Society for Microbiology

RESUMO

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

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