A specific base transition occurs on replicating hepatitis delta virus RNA.
AUTOR(ES)
Luo, G X
RESUMO
Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=249212Documentos Relacionados
- Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA.
- Regulation of polyadenylation of hepatitis delta virus antigenomic RNA.
- RNA conformational requirements of self-cleavage of hepatitis delta virus RNA.
- Genotype-Specific Complementation of Hepatitis Delta Virus RNA Replication by Hepatitis Delta Antigen
- Mutagenesis analysis of the self-cleavage domain of hepatitis delta virus antigenomic RNA.
