A systematic study of low-resolution recognition in protein–protein complexes

AUTOR(ES)

Vakser, Ilya A.

FONTE

The National Academy of Sciences

RESUMO

A comprehensive nonredundant database of 475 cocrystallized protein–protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking program gramm was used to delete the atom-size structural details and systematically dock the resulting molecular images. The results reveal the existence of the low-resolution recognition in 52% of all complexes in the database and in 76% of the 113 complexes with an interface area >4,000 Å2. Limitations of the docking and analysis tools used in this study suggest that the actual number of complexes with the low-resolution recognition is higher. However, the results already prove the existence of the low-resolution recognition on a broad scale.

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