A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.

AUTOR(ES)

Wilson, A G

RESUMO

OBJECTIVE--To determine whether a polymorphism within the tumour necrosis factor alpha (TNF alpha) gene is associated with susceptibility to, or severity of, rheumatoid arthritis (RA). METHODS--Consecutive patients with recent onset RA were enrolled in a prospective trial. DNA was collected, disease activity was measured at presentation, and radiographic progression at three years was assessed. Typing of TNF alpha was by polymerase chain reaction and single stranded conformation polymorphism analysis. RESULTS--No association of TNF alpha alleles and susceptibility to, or severity of, RA was demonstrated. CONCLUSIONS--These results indicate that this TNF alpha polymorphism does not play a part in the genetic background of RA.

Documentos Relacionados

• Giant cell tumour associated with rheumatoid arthritis.
• Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.
• A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.
• Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
• Neuromuscular disorders associated with rheumatoid arthritis.