A Type-C Virus in Human Rhabdomyosarcoma Cells After Inoculation into NIH Swiss Mice Treated with Antithymocyte Serum
AUTOR(ES)
Todaro, George J.
RESUMO
A type-C RNA virus has been isolated that replicates readily in human and other primate cells. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. Various other human tumor cells, similarly transplanted, remained free of overt type-C virus expression. The virus growing in the RD cells, AT-124, has a group-specific antigen and an RNA-dependent DNA polymerase immunologically related to murine type-C viruses, but a host range similar to that of the RD-114 virus. The new isolate is either a previously undescribed, endogenous type-C virus from NIH Swiss mice or a recombinant with both mouse and human type-C genetic information.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=433375Documentos Relacionados
- Type-C RNA Virus Gene Expression in Human Tissue
- Natural human antibodies reactive with primate type-C viral antigens.
- Host-Gene Control of Type-C RNA Tumor Virus Expression and Tumorigenesis in Inbred Mice
- Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum.
- Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.
