AÃÃo analgÃsica central da Dioclea grandiflora em camundongos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Dioclea grandiflora is popular known as âmucunÃâ, âmucunÃ-de-caroÃoâ and âolho-de-boiâ and in Brazil it is spread in caatinga and corral regions. This work, as an experimental study, aimed to identify a possible central analgesic effect of hydroalcoholic and aqueous extracts of stem bark of Dioclea grandiflora administered by intraperitoneal route in mice at doses of 30, 60 and 120 mg / kg, also the effect of the tolerance dose of 30 mg / kg, by chronic treatment for 21 consecutive days. Hot plate, tail-immersion and acetic acid-induced writhing tests were used. In the acute treatment it was observed a significant effect antinoceptive (p <0.05). This effect was inhibited by naloxone, morfinomimetic specific antagonist of opioid receptor. Whereas in the immersion test of the tail, in chronic treatment, only the hydroalcoholic extract, at a dose of 30 mg / kg showed tolerance. It is concluded that the hydroalcoholic and aqueous extracts have central analgesic action and only hydroalcoholic extract shows tolerance when administered chronically, that is typical of opioids

ASSUNTO(S)

odontologia hydroalcoholic extract dioclea grandiflora analgesia extrato aquoso analgesia extrato hidroalcoÃlico aqueous extracts dioclea grandiflora

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