Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)–deficient mice
AUTOR(ES)
Miettinen, Helena E.
FONTE
American Society for Clinical Investigation
RESUMO
Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the cholesterol-lowering drug probucol. This suggests that abnormal lipoprotein metabolism can cause murine infertility — implying a functional hepatic-ovarian axis — and may contribute to some forms of human female infertility.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=200987Documentos Relacionados
- Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
- Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI
- Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility
- HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner
- A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism