Ação da angiotensina II associada ao bloqueio dos receptores AT1 e AT2 no processo inflamatório das lesões vasculares. / Action of angiotensin II associated with the blockade of AT1 and AT2 receptors in the inflammatory process of vascular lesions.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The study hypothesis is that the angiotensin II (Ang II) is capable of triggering inflammatory processes that comprise the initial part of the mechanisms involved in vascular injury or in progress. The objectives were to evaluate the expression of early markers of inflammation in response to the action of Ang II and which receptor (AT1 and AT2) this would lead to the expression of these inflammatory markers. The study was conducted in male C57Bl/6J mice undergoing treatment with subpressor doses of AngII, blockers of AT1 and AT2 receptors and a combination thereof. Treatment times were determined using a time-response curve performed with injections of AngII. After definition of time curve were prepared six animal groups: control, treated Ang II, losartan, Ang II + losartan, PD123319 and Ang II + PD123319. Evaluations were made in the hearts of inflammatory markers by immunohistochemistry for IL-1b and IL-6, TNFa, TGF-b and MCP-1, the adhesion TNF-a serum by ELISA.

ASSUNTO(S)

adhesion molecula angiotensin ii angiotensina ii cardiovascular cardiovascular citocinas cytokine marcadores inflamatórios markers of inflammation moléculas de adesão receptor at1 and at2 receptores at1e at2 renin-angiotensin sistema renina-angiotensina

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