Ação do vinho tinto sobre o sistema nervoso simpático e função endotelial em pacientes hipertensos e hipercolesterolêmicos / Red wine ingestion action upon sympathetic nervous system and endothelial function in hypertensive and hypercholesterolemic subjects

AUTOR(ES)

Ana Cristina Magalhães Andrade

DATA DE PUBLICAÇÃO

2006

RESUMO

Introduction: Moderate red wine intake is inversely associated with development of cardiovascular disease. Red wine effects in sympathetic activity and vascular reactivity are not fully understood. Methods: Muscle sympathetic nerve activity and flow mediated dilatation of brachial artery by ultrasound were evaluated in 10 hypercholesterolemic, 9 hypertensive, and 7 controls subjects before and after red wine intake during 15 days. Hemodynamic measures were done with Finometer: arterial blood pressure, heart rate, cardiac output, and systemic vascular resistance were assessed during mycroneurography. The sympathetic activity was evaluated during baseline, cold test and isometric exercise. Results: After 15 days of red wine intake, sympathetic activity increased significantly in hypertensives and hypercholesterolemics (p <0.05). On the other hand, flow mediated dilation increased after red wine only in hypercholesterolemics (p <0.05). Systolic and diastolic blood pressure as well as heart rate did not change significantly. Cardiac output increased in controls and systemic vascular resistance decreased during cold test in controls. Conclusion: There were similar increases in sympathetic activity in hypertensive and hypercholesterolemic subjects; however, endothelial function was restored only in the latter group, which suggests different mechanisms regulating endothelial function.

ASSUNTO(S)

sistema nervoso simpático hypertension hypercholesterolemia hipercolesterolemia endotélio/ultrasonografia vinho wine hipertensão sympathetic nervous system endothelium/ultrasonography

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