Acetoxycycloheximide-Induced Transient Amnesia: Protective Effects of Adrenergic Stimulants

AUTOR(ES)

Serota, Roger G.

RESUMO

It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug-induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D-amphetamine.

Documentos Relacionados

• Acetoxycycloheximide and Transient Amnesia in the Rat
• Transient global amnesia: an extensive case report.
• Transient global amnesia: an intriguing yet benign disturbance
• Transient global amnesia: clinical features and prognostic factors suggesting recurrence
• Syndromes of transient amnesia: towards a classification. A study of 153 cases.