Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference
AUTOR(ES)
Ross, Robert S.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The social transmission of food preference task (STFP) has been used to examine the involvement of the hippocampus in learning and memory for a natural odor-odor association. However, cortical involvement in STFP has not been extensively studied. The orbitofrontal cortex (OFC) is important in odor-guided learning, and cholinergic depletion of the entire neocortex results in impairments in STFP. Here we examined the specific role of cholinergic modulation in the OFC by assessing the effect of 192 immunoglobulin G-saporin infusion directly into OFC prior to training on STFP. Cholinergic depletion in the OFC impaired expression of the socially transmitted odor association measured 2 d after training, indicating that cholinergic function in the OFC is essential for this form of associative learning.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1142459Documentos Relacionados
- Hippocampal overexpression of mutant creb blocks long-term, but not short-term memory for a socially transmitted food preference
- Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals
- Orbitofrontal cortex: A key prefrontal region for encoding information
- Lesions of the orbitofrontal cortex do not affect the reinforcement omission effect in rats
- Extracellular Signal-Regulated Kinase Activity in the Entorhinal Cortex Is Necessary for Long-Term Spatial Memory