AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii
AUTOR(ES)
Ruzin, Alexey
FONTE
American Society for Microbiology
RESUMO
Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 μg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 μg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=547285Documentos Relacionados
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