Action of soybean on the thryroid of rats: inluence of the iodine of the ration / Ação da soja sobre a tireóide de ratos: influência do iodo da ração

AUTOR(ES)
DATA DE PUBLICAÇÃO

1985

RESUMO

Defatted autoclaved soybean flour presented a water/acetone soluble fraction which is able to depress I-131uptake by rat thyroids tested in 24hs "in vivo" or in 3hs "in vitro" assays. When this fraction was given to rats in ration with either normal or deficient iodine content for periods from 7 to 84 days no significant action was detected. On the other hand a factor associated to the high molecular weight protein fraction was identified. The factor is active in rats starting from 14 days after ingestion, in rations with low iodine content producing: increase in thyroid weight, lowering of I-131 uptake, alteration on MIT/DIT, T3/T4 ratios and after 84 days of administration a significant reduction of serum T4 and a large decrease of the colloid content of follicle. Hydrolysis by pepsin or pancreatin does not eliminate the observed action. The mechanism of action of this factor seems to the related to a blockage of the iodine uptake.

ASSUNTO(S)

thyroid soybean iodo da ração iodine of the ration soja tireóide

ACESSO AO ARTIGO

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