Activation of human blood monocytes by products of sensitized lymphocytes.

AUTOR(ES)

Rocklin, R E

RESUMO

Studies were carried out to determine whether products of activated human lymphocytes altered human monocyte function. Supernatants from sensitized human lymphocytes stimulated by specific antigen were cultured with monolayers of human monocytes. Such monocytes exhibited enhanced adherence to their culture vessels and increased glucose carbon-1 oxidation after 2-3 days of incubation. The substance responsible for these effects was found to elute from Sephadex G-100 gel columns in a fraction with 23,000 mol wt, the same fraction containing human migration inhibitory factor.

Documentos Relacionados

• Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes.
• Specific in vitro antimannan-rich antigen of Candida albicans antibody production by sensitized human blood lymphocytes.
• Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.
• Cell-mediated immune response to bacterial products in human tonsils and peripheral blood lymphocytes.
• Activation of CFTR chloride current by nitric oxide in human T lymphocytes.