Activities of Dicationic Compounds against Trichomonas vaginalis

AUTOR(ES)

Crowell, Andrea L.

FONTE

American Society for Microbiology

RESUMO

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

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