Acute hypotensive and diuretic activities of Berberis vulgaris root bark aqueous extract in normal rats

AUTOR(ES)

Ahmed, Muhammad, Azmat, Aisha, Khan, Salahuddin

FONTE

Braz. J. Pharm. Sci.

DATA DE PUBLICAÇÃO

05/03/2018

RESUMO

ABSTRACT The aim of this study is to investigate the effectiveness of intravenous administration of Berberis vulgaris root bark aqueous extract (BRBD) on the cardiovascular and renal functions of healthy normotensive rats. The different doses of BRBD 1, 10 and 20 mg/kg were administered intravenously (i.v) in normal rats. Blood pressure, diuretic activity and serum renal profile were analyzed. Intravenous injection of BRBD at the different doses of 1, 10 and 20 mg/kg showed a dose-dependent reduction in mean arterial blood pressure (P<0.001). At different doses of 1, 10 and 20 mg/kg, the hypotensive effect remained for more than one hour. Single dose administration of BRBD at doses of 10 and 20 mg/kg caused a significant increase in urine output (P<0.001) as compared to the control rats. Serum renal profile test (albumin, Urea, Uric Acid, creatinine and BUN) did not show any significant alteration. The authors conclude that the BRBD is a potent hypotensive and possesses diuretic potential

Documentos Relacionados

• Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract
• Antidiabetic activity of Pseudarthria viscida aqueous root extract in neonatal streptozotocin-induced NIDDM rats
• Evaluation of antinociceptive and anti-inflammatory activities of extract and fractions of Eugenia jambolana root bark and isolation of phytoconstituents
• Atriopeptin III. A potent natriuretic, diuretic, and hypotensive agent in rats with chronic renal failure.
• Salacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profile