Adhesion of Gardnerella vaginalis to vaginal epithelial cells: variables affecting adhesion and inhibition by metronidazole.
AUTOR(ES)
Peeters, M
RESUMO
Variables affecting the adherence of Gardnerella vaginalis to human vaginal epithelial cells were examined in vitro. Adherence depended on pH, with maximum attachment occurring between pH 5 and pH 6. Preincubation of the bacteria at 56 degrees C for 30 minutes and ultraviolet irradiation resulted in a noticeable decrease in adherence. In contrast, adherence was not altered by preincubating the epithelial cells under these conditions. Periodate oxidation of the vaginal cells caused an appreciable reduction in subsequent adherence of G vaginalis. None of the 19 single carbohydrates tested inhibited adherence completely. Metronidazole at subinhibitory concentrations for G vaginalis, appreciably reduced the adhesive capacity of G vaginalis, whereas subinhibitory concentrations of ampicillin did not.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1011867Documentos Relacionados
- Growth inhibition of metronidazole-susceptible and metronidazole-resistant strains of Gardnerella vaginalis by Lactobacilli in vitro.
- Chemotaxis inhibition by Gardnerella vaginalis and succinate producing vaginal anaerobes: composition of vaginal discharge associated with G vaginalis.
- Studies on strain sensitivity of Trichomonas vaginalis to metronidazole.
- Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole.
- Specific parasitism of purified vaginal epithelial cells by Trichomonas vaginalis.
