Adipose conversion of 3T3 cells depends on a serum factor.
AUTOR(ES)
Kuri-Harcuch, W
RESUMO
The adipose conversion of 3T3-F442A cells depends on an adipogenic factor in serum. In the presence of this factor, cells grown to confluence become spherical, greatly increase the activity of their lipogenic enzymes, and accumulate triglyceride. In the absence of the adipogenic factor, the cells grow normally, but when they reach confluence they do not become spherical, do not accumulate triglyceride, and do not undergo any increase in activity of lipogenic enzymes. In cattle there is a great deal more of the adipogenic factor in the serum before birth than in the serum of grown animals. The nature of the adipogenic factor suggests that it may play an important role in the development of adipose tissue.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=393127Documentos Relacionados
- Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.
- Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.
- A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker
- A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor.
- Effect of a Fibroblast Growth Factor, Insulin, Dexamethasone, and Serum on the Morphology of BALB/c 3T3 Cells