Agalactosyl glycoforms of IgG autoantibodies are pathogenic.
AUTOR(ES)
Rademacher, T W
RESUMO
The glycosylation of IgG results in many different glycoforms. A large body of correlative data (including remission of arthritis during pregnancy) has suggested that IgG molecules lacking galactose were associated with rheumatoid arthritis. We now demonstrate that agalactosyl IgG glycoforms are directly associated with pathogenicity in murine collagen-induced arthritis. We show that passive transfer of an acute synovitis in T-cell-primed mice can be enhanced by using IgG containing autoantibodies to type II collagen when the antibodies are present as the agalactosyl glycoform. Thus, nonpathogenic doses of autoantibodies can be made pathogenic by altering their glycosylation state.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=44150Documentos Relacionados
- IgG Anti-IgE Autoantibodies in Visceral Leishmaniasis
- Agalactosyl IgG, antibodies to heat shock proteins, and acute rheumatic fever.
- Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity.
- Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
- Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM