Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. I. Characteristics of Mutants and Genetic Mapping of Alleles

AUTOR(ES)

Korch, Christopher T.

RESUMO

A number of his1 mutants were tested for suppressibility, for reversion by EMS, ICR-170, and nitrous acid, for their allelic complementation response, and for their temperature sensitivity and osmotic remediability. None of 52 mutants tested was suppressible by a known ochre suppressor. This is a very surprising result compared with other studies of suppressibility in yeast and suggests that another function essential to the cell is associated with the his1 gene product, the polarity effect of a nonsense mutation destroying the activity of the his1 enzyme and this second function.

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