Allelic exclusion of immunoglobulin expression is not caused by somatic segregation
AUTOR(ES)
Wabl, Matthias R.
RESUMO
We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345794Documentos Relacionados
- A theory of allelic and isotypic exclusion for immunoglobulin genes.
- Membrane-Associated Immunoglobulin of Rabbit Peripheral Blood Lymphocytes: Allelic Exclusion at the b Locus
- The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion
- Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.
- Allelic exclusion in rat kappa immunoglobulin chains: extent of Jk rearrangement in normal B lymphocytes.
