Allelic Variation within the Emv-15 Locus Defines Genomic Sequences Closely Linked to the agouti Locus on Mouse Chromosome 2
AUTOR(ES)
Siracusa, Linda D.
RESUMO
Gene(s) at the agouti locus act within the microenvironment of the hair follicle to switch pigment synthesis in the melanocyte between eumelanin (black or brown pigment) and phaeomelanin (yellow pigment). Many phenotypic variants of this locus have been described. The mechanism(s) of gene action causing such variation in coat-color phenotype is not known. The close linkage of an endogenous ecotropic murine leukemia provirus, Emv-15 , to the lethal yellow mutation of the agouti locus provides a means to molecularly access genes at or near the agouti locus. We have identified and used a unique mouse sequence flanking the Emv-15 provirus to define three alleles of the Emv-15 locus. We found a correlation between the presence of specific Emv-15 alleles and the origins of specific agouti locus mutations, confirming close linkage. However, we found some exceptions which suggest that the Emv-15 locus is closely linked to, but genetically separable from, the agouti locus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1203190Documentos Relacionados
- The Locus Encoding αa-Crystallin Is Closely Linked to H-2K on Mouse Chromosome 17
- Opposite Orientations of an Inverted Duplication and Allelic Variation at the Mouse Agouti Locus
- Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1.
- A lymphocyte antigen encoded by a locus closely linked to H-3 on the second chromosome of the mouse.
- The Hox-2 Homeo Box Gene Complex on Mouse Chromosome 11 Is Closely Linked to Re