Allopurinol metabolism in a patient with xanthine oxidase deficiency.
AUTOR(ES)
Yamanaka, H
RESUMO
A patient with complete deficiency of xanthine oxidase would not be expected to oxidase allopurinol to oxipurinol if allopurinol did not have any alternative metabolic pathway. 400 mg of allopurinol was administered to a patient with xanthine oxidase deficiency, and plasma allopurinol, oxipurinol, hypoxanthine, and xanthine levels were determined serially by the use of high-performance liquid chromatography (HPLC). Plasma oxipurinol as well as allopurinol was increased after the administration of allopurinol, and oxipurinol reached a maximum level of 13.1 micrograms/ml at 6 hours after the administration. This was the same pattern as that of normal controls. This result demonstrated the existence of some other oxidising enzyme of allopurinol than xanthine oxidase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001330Documentos Relacionados
- Exertional rhabdomyolysis in a patient with calcium adenosine triphosphatase deficiency.
- Corneal ulceration in a patient with alpha 1 antitrypsin deficiency.
- Acute myeloid leukaemia in a patient with congenital antithrombin III deficiency.
- Endocrine involvement in mitochondrial encephalomyopathy with partial cytochrome c oxidase deficiency.
- Inhibition of xanthine oxidase by allopurinol: a therapeutic option for ischaemia induced pathological processes?