Alpha-aminoisobutyric acid transport in human leukemic lymphocytes: in vitro characteristics and inhibition by cortisol and cycloheximide
AUTOR(ES)
Baran, Daniel T.
RESUMO
We have studied the transport of alpha-aminoisobutyric acid (AIB)-3-14C and its response to cortisol and cycloheximide in vitro in blood lymphocytes from untreated patients with chronic lymphocytic leukemia. The accumulation of AIB-3-14C increased in a linear fashion for 60 min, and reached an apparent steady state in 120 min. The initial rate of AIB accumulation (Vo) varied from 1.1 to 10.2 μmoles/kg cell H2O per min in cells from 16 different patients; however, Vo was reproducible in cells from five of six patients which were studied repeatedly over 1-9 months, and correlated positively with the lymphocyte count (r = 0.51, P = < 0.01).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292375Documentos Relacionados
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