Alterações do metabolismo de macrófagos e linfócitos após a perda de peso em ratos envelhecidos: efeito da restrição calórica ou do exercício aeróbio. / Changes of lymphocytes and macrophages metabolism after weight loss in aging rats: Effects of a hipocaloric diet or an aerobic exercise program

AUTOR(ES)

Marcela Oliveira Meneguello

DATA DE PUBLICAÇÃO

2000

RESUMO

Ageing is marked by several kinds of physiological changes, among then we find an increase of fat mass and a decline in several aspects of the immune system. It is well understood the intrinsical connexion between the increase in body fat and the risk of related diseases and the one question that remains is about the influence over the immune system response, since these two factors are altered on the ageing process. The purpose of this study was to investigate the relationship among fat content and immune cells of the aging rats. For this, in one first study, we used ADULTS and AGEING rats to determine the changes found in the ageing process. In the second time, the AGEING rats were submitted to two protocols for weight loss (slimming), 50% of caloric restriction (CR) and aerobic exercise (swimming) (EX), for four or six weeks. In this way, we can study some parameters of macrophages and lymphocytes metabolism in ageing rats with different body fat content. In the first study, the results confirmed the fat increase as well as some changes in the immune system of the ageing rats, especially in the macrophages functional capabilities. In the second study, the results showed that both protocols decreased body fat and weight, with the best results happening with CR protocol. The immune system had an increase on the phagocytic response and H2O2 production for macrophages and alterations of the proliferative capacities of the lymphocytes, in both protocols.

ASSUNTO(S)

aerobic exercise macrophage macrófagos restrição calórica weight loss envelhecimento exercício aeróbio sistema imunológico lymphocyte caloric restriction emagrecimento linfócitos aging immune system

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