Amiloide, amiloidose e proteina serica amiloide : frequencia e importanciana artrite reumatoide e esclerose sistemica

AUTOR(ES)
DATA DE PUBLICAÇÃO

1994

RESUMO

The amyloid protein(AA) deposited in rheumatic diseases is derived from serum amylid protein A (SAA). The purposes of the present study were to verifythe frequency of amyloidoses in rheumatoid arthrits (RA) and systemic sclerosis (SSc) through the evaluation of subcutaneous abdominal fat biopsy and to determine the SAA response associated with amyloidosis, clinical features and disease activity in 48 patients with RA and 39 with SS. The fat biopsy specimens were stained with Congo red, examined for green birefringence through a polarizing microscope and showed positive results in two Caucasian women with RA (4,17%), high SAA levels, long standing disease proteinuria and positive rheumatoid factor and negative results in SSc patients. Congo red staining of subcutaneous fat tissue biopsu is a simples and sensitve method for the diagnosis of systemic amyloidosis. It may be recommended because of the low risk of complications from bleeding and lower costs than more invasive biopsy procedures. SAA levels were determined by solid phase enzyme immunoassay in sera from 43 healthy volunteers, 46 patients with RA and 37with SSc. There were significant differences in SAA concentration between RA and control groups and patients with or without arthristis and SAA levels under 100ug/ml. The patients with SSc were divided in two groups, 26 having limited systemic sclerosis (ISSc) and 13 having diffuse systemic sclerosis(dSSc). There wre significant differences in SAA concentration, mean disease duration, total skin score and proteinuria between ISS and dSSc groups. SAA is a sensitive acute phase reactant that reflects the inflammatory activity of rheumatic diseases. diseases

ASSUNTO(S)

artrite reumatoide escleroderma sistemico amiloidose proteinas - análise

ACESSO AO ARTIGO

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