Amitriptyline in migraine prophylaxis: Changes in pattern of attacks during a controlled clinical trial

AUTOR(ES)

Gomersall, James D.

RESUMO

A double-blind controlled clinical trial of crossover design was conducted in 26 volunteers suffering from migraine. Of 20 subjects who completed the trial, 16 had fewer attacks on amitriptyline than on placebo. Amitriptyline was found to have the greatest effect in reducing attacks with a short warning and in which no specific cause could be recognized. It had least effect in attacks with a long warning and recognized as due to fatigue. The drug was effective only in reducing those attacks with shorter duration and its effect was irrespective of severity. A dosage of between 10 and 60 mg, usually taken at night, was found to be adequate.

Documentos Relacionados

• The effectiveness of propranolol, flunarizine, amitriptyline and botulinum toxin in vestibular migraine complaints and prophylaxis: a non-randomized controlled study
• Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients
• Psychological changes during a controlled trial of rehabilitation in chronic respiratory disability.
• Temporal lobe phenomena during the aura phase of migraine attacks.
• Endocarditis prophylaxis: Do parents remember advice?