An enhancer responsible for activating transcription at the midblastula transition in Xenopus development.

AUTOR(ES)

Krieg, P A

RESUMO

Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-beta-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.

Documentos Relacionados

• Translation of Maternal TATA-Binding Protein mRNA Potentiates Basal but Not Activated Transcription in Xenopus Embryos at the Midblastula Transition
• Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
• A developmental timer regulates degradation of cyclin E1 at the midblastula transition during Xenopus embryogenesis.
• The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage
• Transcription enhancer factor-1 (TEF-1) DNA binding sites can specifically enhance gene expression at the beginning of mouse development.