An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

AUTOR(ES)

Magro, D.A.C., Hohmann, M.S.N., Mizokami, S.S., Cunha, T.M., Alves-Filho, J.C., Casagrande, R., Ferreira, S.H., Liew, F.Y., Cunha, F.Q., Verri Jr, W.A.

FONTE

Braz J Med Biol Res

DATA DE PUBLICAÇÃO

16/07/2013

RESUMO

Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.

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