An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.
AUTOR(ES)
Lagenaur, C
RESUMO
The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=299379Documentos Relacionados
- On exponential smoothing: an extension.
- Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.
- Structure of the gene for the liver cell adhesion molecule, L-CAM.
- Overexpression of a Novel Lymphocyte Population, Positive for an Intracellular CD14-Like Antigen, in Patients Positive for Human Immunodeficiency Virus Type 1
- Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM.
