An oligopurine sequence bias occurs in eukaryotic viruses.

AUTOR(ES)

Beasty, A M

RESUMO

Twenty four DNA and RNA viral nucleotide sequences, comprising over 346 kilobases, have been analyzed for the occurrence of strings of contiguous purine or pyrimidine residues. On average strings greater than or equal to 10 contiguous purines or pyrimidines are found three and a half times more frequently than would be expected for a random distribution of bases. Detailed analysis of the 172 kilobase Epstein-Barr viral sequence shows that the bias in favor of contiguous purine residues increases with the length of the purine string. These findings are similar to those seen for genomic DNA from higher eukaryotes. In contrast no overrepresentation of oligopurine or oligopyrimidine strings is observed in 52 kilobases from eight bacteriophage and E. coli DNA sequences.

Documentos Relacionados

• Self-splicing group I introns in eukaryotic viruses.
• An overabundance of long oligopurine tracts occurs in the genome of simple and complex eukaryotes.
• Quantitative nucleotide sequence relationships of mammalian RNA tumor viruses.
• Fungal viruses.
• Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses.