An Rme1-Independent Pathway for Sporulation Control in Saccharomyces Cerevisiae Acts through Ime1 Transcript Accumulation
AUTOR(ES)
Kao, G.
RESUMO
The RES1-1 mutation was isolated on the basis of its ability to allow MATa/MATα diploid Saccharomyces cerevisiae cells to express a late sporulation-regulated gene, SPR3, in the presence of excess copies of RME1. RME1 is a repressor of meiosis that is normally expressed in cells that lack the a1/α2 repressor encoded by MAT. The RES1-1 mutation also supports sporulation in mat-insufficient diploids. This phenotype does not result from a failure to express RME1 and is not due to activation of the silent copies of mating type information. RES1-1 activates sporulation by allowing IME1 accumulation in all cell types, irrespective of the presence of the MAT products. IME1 is still responsive to RME1 in RES1-1 cells, since double mutants (rme1 RES1-1) that are deficient at MAT can sporulate better than either single mutant. RES1-1 is not an allele of IME1.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1204281Documentos Relacionados
- Positive control of sporulation-specific genes by the IME1 and IME2 products in Saccharomyces cerevisiae.
- Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae.
- Saccharomyces cerevisiae exhibits a sporulation-specific temporal pattern of transcript accumulation.
- rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation.
- Ime2, a Meiosis-Specific Kinase in Yeast, Is Required for Destabilization of Its Transcriptional Activator, Ime1
