Analysis of the Dosage Compensation of a Specific Transcript in DROSOPHILA MELANOGASTER
AUTOR(ES)
Breen, Thomas R.
RESUMO
The amount of steady-state level RNA complementary to the X-linked salivary gland secretion polypeptide gene Sgs-4 was measured in male and female third-instar larvae carrying one or two doses of a wild-type allele of the gene. RNA levels were found to be compensated in normal one-dose males and two-dose females and to be dosage-dependent within each sex. The presence of mutant alleles of male-less (mle) was found to reduce the level of Sgs-4 transcripts in males. These results support the contentions that dosage compensation is mediated by regulating the level of X-linked gene transcripts and that a product of the mle+ gene is involved in this process.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1202759Documentos Relacionados
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