Analysis of tuberculous meningitis cases by an immunoblotting assay based on a mycobacterial antigen complex.

AUTOR(ES)

Zou, Y L

RESUMO

Tuberculous meningitis cases were analyzed by an immunoblotting test based on Mycobacterium bovis BCG antigen complex A60. Anti-A60 immunoglobulin G (IgG) in cerebrospinal fluid (CSF) allowed early diagnosis, and concentrations decreased after recovery. In primary meningitis forms, anti-A60 IgGs were intrathecally synthesized and specific oligoclonal IgGs were present in CSF. In meningeal complications of pulmonary tuberculosis, there were matching titers of anti-A60 IgG in blood and CSF (mirror pattern). Correlation between CSF-restricted patterns and CSF pleocytosis was shown.

Documentos Relacionados

• Intrathecal synthesis of anti-mycobacterial antibodies in patients with tuberculous meningitis. An immunoblotting study.
• Rapid Diagnosis of Tuberculous Meningitis by a Dot Immunobinding Assay To Detect Mycobacterial Antigen in Cerebrospinal Fluid Specimens
• Non-tuberculous mycobacterial keratitis: a study of 22 cases.
• Evidence for three separate genes encoding the proteins of the mycobacterial antigen 85 complex.
• Three-dimensional structure of an antibody-antigen complex.