Analytic models for mechanotransduction: Gating a mechanosensitive channel

AUTOR(ES)

Wiggins, Paul

FONTE

National Academy of Sciences

RESUMO

Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story that can provide both a quantitative comparison with measurements of opening tension for MscL when reconstituted in bilayers of different thickness, and qualitative insights into the function of the MscL channel and other transmembrane proteins.

Documentos Relacionados

• Gating the bacterial mechanosensitive channel MscL in vivo
• State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation*
• Conformational pathways in the gating of Escherichia coli mechanosensitive channel
• One face of a transmembrane helix is crucial in mechanosensitive channel gating
• Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli.