Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins
AUTOR(ES)
Epple, Petra
FONTE
National Academy of Sciences
RESUMO
The most familiar form of plant programmed cell death is the hypersensitive response (HR) associated with successful plant immune responses. HR is preceded by an oxidative burst and the generation of both reactive oxygen intermediates (ROI) and NO. The Arabidopsis LSD1 gene encodes a negative regulator of plant programmed cell death that meets several criteria for a regulator of processes relevant to ROI management during pathogen responses. Here we demonstrate that a highly conserved LSD1 paralogue, LOL1, acts as a positive regulator of cell death. Manipulation of LOL1 expression alters both the superoxide-dependent, runaway cell death phenotype of lsd1 plants and the normal HR. We also show that LSD1 and LOL1 have antagonistic effects on copper-zinc superoxide dismutase accumulation, consistent with functions in cell death control via maintenance of ROI homeostasis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=164532Documentos Relacionados
- Oxidative Stress-Induced Calcium Signaling in Arabidopsis1
- High susceptibility of activated lymphocytes to oxidative stress-induced cell death
- Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death
- The Plant-Specific Database. Classification of Arabidopsis Proteins Based on Their Phylogenetic Profile1
- Functional Analysis of Arabidopsis Ethylene-Responsive Element Binding Protein Conferring Resistance to Bax and Abiotic Stress-Induced Plant Cell Death1