Antianaerobic Activity of a Novel Fluoroquinolone, WCK 771, Compared to Those of Nine Other Agents

AUTOR(ES)

Peric, Mihaela

FONTE

American Society for Microbiology

RESUMO

Agar dilution MIC methodology was used to compare the activity of WCK 771 with those of ciprofloxacin, levofloxacin, moxifloxacin, gatifloxacin, piperacillin, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 350 anaerobes. Overall, the MICs (in micrograms per milliliter) at which 50 and 90%, respectively, of the isolates tested were inhibited were as follows: WCK 771, 0.5 and 2.0; ciprofloxacin, 2.0 and 32.0; levofloxacin, 1.0 and 8.0; gatifloxacin, 0.5 and 4.0; moxifloxacin, 0.5 and 4.0; piperacillin, 2.0 and 64.0; piperacillin-tazobactam, ≤0.125 and 8.0; imipenem, 0.125 and 1.0; clindamycin, 0.125 and 16.0; and metronidazole, 1.0 and >16.0.

Documentos Relacionados

• Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models
• Antipneumococcal Activities of Gemifloxacin Compared to Those of Nine Other Agents
• Time-Kill Studies of the Antianaerobe Activity of Garenoxacin Compared with Those of Nine Other Agents
• Antipneumococcal Activity of BMS 284756 Compared to Those of Six Other Agents
• Antipneumococcal Activity of Ertapenem (MK-0826) Compared to Those of Other Agents