Antibiotic Synthesis and Morphological Differentiation of Cephalosporium acremonium
AUTOR(ES)
Nash, C. H.
RESUMO
In submerged cultures, Cephalosporium acremonium exists in four morphological forms: hyphae, arthrospores, conidia, and germlings. The phase of hyphal differentiation into arthrospores coincides with the maximum rate of β-lactam antibiotic synthesis. Furthermore, arthrospores, separated by density-gradient centrifugation, possess 40% greater antibiotic-producing activity than any other morphological cell type. In a series of mutants, each with an increased potential to produce β-lactam antibiotics, differentiation into arthrospores was proportional to the increased titer of these antibiotics. Thus, arthrospores exhibit enhanced synthesis of β-lactam antibiotics and appear to be a determining factor in high-yielding mutants. Since a non-antibiotic-producing mutant readily differentiated into arthrospores, antibiotic synthesis and cellular differentiation are not obligately related.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=377366Documentos Relacionados
- Synthesis of Deactoxycephalosporin C by a Mutant of Cephalosporium acremonium
- Synthesis of Deactyoxycephalosporin C by a Mutant of Cephalosporium acremonium
- Synthesis of Cephalosporin C from Sulfate by Mutants of Cephalosporium acremonium
- Virus-Like Particles in Cephalosporium acremonium
- Glutamate Dehydrogenase Specific Activity and Cephalosporin C Synthesis in the M8650 Series of Cephalosporium acremonium Mutants