Antibody-dependent cellular cytotoxicity of Trypanosoma cruzi: characterization of the effector cell from normal human blood.

AUTOR(ES)

Madeira, E D

RESUMO

The antibody-dependent cellular cytotoxicity activity of normal human blood cells against epimastigotes of Trypanosoma cruzi was measured by the release of incorporated [3H]uridine. Sera from patients with chronic Chagas' disease were used to sensitize the parasites to the lytic activity of the effector cells. Different steps of peripheral blood cell purification were employed, and different cell subpopulations were tested as effectors in the system. The main cytotoxic activity was detected in the granulocyte-rich fraction.

Documentos Relacionados

• Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with Trypanosoma cruzi.
• Mechanisms of antibody-dependent cellular cytotoxicity: the use of effector cells from chronic granulomatous disease patients as investigative probes.
• Human Monocyte Antibody-Dependent Cell-Mediated Cytotoxicity to Tumor Cells
• Ability of human cord blood lymphocytes to mediate antibody-dependent cellular cytotoxicity against influenza virus-infected cells.
• Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations.