Antibody Response to Cryptococcus neoformans Proteins in Rodents and Humans
AUTOR(ES)
Chen, Lin-Chi
FONTE
American Society for Microbiology
RESUMO
The prevalence and specificity of serum antibodies to Cryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcosis, in matched samples from HIV-positive individuals who did not develop cryptococcosis, and in HIV-negative individuals. Rodents had little or no serum antibody reactive with C. neoformans proteins prior to infection. The intensity and specificity of the rodent antibody response were dependent on the species, the mouse strain, and the viability of the inoculum. All humans had serum antibodies reactive with C. neoformans proteins regardless of the potential exposure, the HIV infection status, or the subsequent development of cryptococcosis. Our results indicate (i) a high prevalence of antibodies reactive with C. neoformans proteins in the sera of rodents after cryptococcal infection and in humans with or without HIV infection; (ii) qualitative and quantitative differences in the antibody profiles of HIV-positive individuals; and (iii) similarities and differences between humans, mice, and rats with respect to the specificity of the antibodies reactive with C. neoformans proteins. The results are consistent with the view that C. neoformans infections are common in human populations, and the results have implications for the development of vaccination strategies against cryptococcosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=115960Documentos Relacionados
- Extracellular proteins of Cryptococcus neoformans and host antibody response.
- Immune Response to Cryptococcus neoformans Soluble Polysaccharide I. Serological Assay for Antigen and Antibody
- Synthesis of Polymerized Melanin by Cryptococcus neoformans in Infected Rodents
- Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents
- Molecular and Idiotypic Analyses of the Antibody Response to Cryptococcus neoformans Glucuronoxylomannan-Protein Conjugate Vaccine in Autoimmune and Nonautoimmune Mice